Drug interactions
Fedratinib + Rolapitant
Severity: Minor
Fedratinib and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor, and rolapitant is metabolized in part by CYP3A4, so rolapitant concentrations may rise. Fedratinib also inhibits CYP2D6, which could increase exposure to certain other substrates, but this is not specific here.
What this interaction means in plain words
Fedratinib and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Fedratinib inhibits CYP3A4, possibly reducing rolapitant clearance.
What to do
No dose adjustment is generally needed; monitor for rolapitant adverse effects such as fatigue and dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Rolapitant?
MediHelp rates the interaction as minor. Fedratinib and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is a moderate CYP3A4 inhibitor, and rolapitant is metabolized in part by CYP3A4, so rolapitant concentrations may rise. Fedratinib also inhibits CYP2D6, which could increase exposure to certain other substrates, but this is not specific here.
How serious is the interaction between Fedratinib and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for rolapitant adverse effects such as fatigue and dizziness.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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