Drug interactions
Fenofibrate + Glipizide
Severity: Moderate
Fenofibrate and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported when they are combined. Fenofibrate can also improve insulin sensitivity, which may add to the effect. The risk is higher in patients with low albumin, renal impairment or reduced food intake.
What this interaction means in plain words
Fenofibrate and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Possible displacement from plasma protein binding combined with additive glucose-lowering pharmacodynamic effects; the evidence for each component is limited.
What to do
Monitor blood glucose more frequently when fenofibrate is started or stopped in a patient taking glipizide. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Glipizide
Frequently asked questions
Can I take Fenofibrate with Glipizide?
MediHelp rates the interaction as moderate. Fenofibrate and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported when they are combined. Fenofibrate can also improve insulin sensitivity, which may add to the effect. The risk is higher in patients with low albumin, renal impairment or reduced food intake.
How serious is the interaction between Fenofibrate and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when fenofibrate is started or stopped in a patient taking glipizide. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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