Drug interactions
Fenofibrate + Insulin degludec-insulin aspart
Severity: Minor
Fenofibrate and Insulin degludec-insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate may modestly improve glycemic control and in rare cases contribute to hypoglycemia in patients on insulin. Clinically important effects are uncommon.
What this interaction means in plain words
Fenofibrate and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
PPAR-alpha activation may improve insulin sensitivity, giving a mild additive effect; the mechanism is not firmly established.
What to do
Be aware of the possibility and monitor blood glucose when fenofibrate is started. Reduce the insulin dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Insulin degludec-insulin aspart?
MediHelp rates the interaction as minor. Fenofibrate and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate may modestly improve glycemic control and in rare cases contribute to hypoglycemia in patients on insulin. Clinically important effects are uncommon.
How serious is the interaction between Fenofibrate and Insulin degludec-insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the possibility and monitor blood glucose when fenofibrate is started. Reduce the insulin dose only if hypoglycemia occurs.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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