Drug interactions
Fenofibrate + Levoketoconazole
Severity: Minor
Fenofibrate and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, but fenofibrate is cleared mainly by glucuronidation rather than CYP3A4. A significant rise in exposure is therefore unlikely. Both drugs can affect liver enzymes, which may be relevant to monitoring.
What this interaction means in plain words
Fenofibrate and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
CYP3A4 inhibition has limited impact on fenofibric acid, which is mainly glucuronidated; overlapping hepatotoxicity is possible.
What to do
No dose change is needed. Monitor liver enzymes, as levoketoconazole labeling requires, and review fenofibrate if they rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fenofibrate with Levoketoconazole?
MediHelp rates the interaction as minor. Fenofibrate and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a strong CYP3A4 inhibitor, but fenofibrate is cleared mainly by glucuronidation rather than CYP3A4. A significant rise in exposure is therefore unlikely. Both drugs can affect liver enzymes, which may be relevant to monitoring.
How serious is the interaction between Fenofibrate and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor liver enzymes, as levoketoconazole labeling requires, and review fenofibrate if they rise.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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