Drug interactions
Fenofibrate + Rucaparib
Severity: Minor
Fenofibrate and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and other enzymes and could raise levels of sensitive substrates. Fenofibrate is cleared mainly by glucuronidation, so a clinically relevant rise is unlikely.
What this interaction means in plain words
Fenofibrate and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, a minor route for fenofibrate, so any effect is predicted only.
What to do
No empiric dose change is needed. Monitor for muscle symptoms and liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fenofibrate with Rucaparib?
MediHelp rates the interaction as minor. Fenofibrate and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 and other enzymes and could raise levels of sensitive substrates. Fenofibrate is cleared mainly by glucuronidation, so a clinically relevant rise is unlikely.
How serious is the interaction between Fenofibrate and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for muscle symptoms and liver enzyme elevation.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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