Drug interactions
Fostamatinib + Mitomycin
Severity: Minor
Fostamatinib and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may raise concentrations of P-gp substrates. Mitomycin exposure could rise, with possible increase in toxicity such as myelosuppression, but clinical data are lacking.
What this interaction means in plain words
Fostamatinib and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Mitomycin belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by the active metabolite of fostamatinib.
What to do
Monitor blood counts and mitomycin toxicity, and reduce the mitomycin dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Mitomycin?
MediHelp rates the interaction as minor. Fostamatinib and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and may raise concentrations of P-gp substrates. Mitomycin exposure could rise, with possible increase in toxicity such as myelosuppression, but clinical data are lacking.
How serious is the interaction between Fostamatinib and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and mitomycin toxicity, and reduce the mitomycin dose if adverse effects develop.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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