Drug interactions
Fostamatinib + Tenofovir alafenamide
Severity: Minor
Fostamatinib and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite R406 inhibits BCRP and may increase exposure to BCRP substrates. Tenofovir alafenamide is affected by BCRP efflux in the gut, so its absorption may increase modestly.
What this interaction means in plain words
Fostamatinib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
R406 inhibits intestinal BCRP (and possibly P-gp) efflux, increasing tenofovir alafenamide absorption.
What to do
No empiric dose change is needed. Monitor for tenofovir adverse effects such as renal changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Fostamatinib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite R406 inhibits BCRP and may increase exposure to BCRP substrates. Tenofovir alafenamide is affected by BCRP efflux in the gut, so its absorption may increase modestly.
How serious is the interaction between Fostamatinib and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for tenofovir adverse effects such as renal changes.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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