Drug interactions
Givosiran + Melatonin
Severity: Minor
Givosiran and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and melatonin is cleared mainly by CYP1A2. Melatonin exposure may rise, causing more drowsiness or prolonged effects.
What this interaction means in plain words
Givosiran and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givosiran belongs to Miscellaneous; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP1A2-mediated melatonin metabolism by givosiran.
What to do
Use the lowest effective melatonin dose and monitor for daytime drowsiness. Lower the dose if excess sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Melatonin?
MediHelp rates the interaction as minor. Givosiran and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can reduce CYP1A2 activity, and melatonin is cleared mainly by CYP1A2. Melatonin exposure may rise, causing more drowsiness or prolonged effects.
How serious is the interaction between Givosiran and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective melatonin dose and monitor for daytime drowsiness. Lower the dose if excess sedation occurs.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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