Drug interactions
Givosiran + Methamphetamine
Severity: Moderate
Givosiran and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces CYP2D6 activity, which can raise exposure to sensitive CYP2D6 substrates. Methamphetamine is partly cleared by CYP2D6, so stimulant effects such as hypertension and tachycardia may increase.
What this interaction means in plain words
Givosiran and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Methamphetamine belongs to Central Nervous System.
Why it happens
Givosiran-associated reduction of CYP2D6 activity slows methamphetamine metabolism.
What to do
Monitor blood pressure, heart rate and stimulant adverse effects, and reduce the methamphetamine dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Methamphetamine?
MediHelp rates the interaction as moderate. Givosiran and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran reduces CYP2D6 activity, which can raise exposure to sensitive CYP2D6 substrates. Methamphetamine is partly cleared by CYP2D6, so stimulant effects such as hypertension and tachycardia may increase.
How serious is the interaction between Givosiran and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and stimulant adverse effects, and reduce the methamphetamine dose if they appear.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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