Drug interactions
Givosiran + Mirtazapine
Severity: Moderate
Givosiran and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces CYP1A2 and CYP2D6 activity, both of which contribute to mirtazapine metabolism. Mirtazapine concentrations may rise, leading to more sedation and other adverse effects.
What this interaction means in plain words
Givosiran and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Mirtazapine belongs to Central Nervous System.
Why it happens
Givosiran-related inhibition of CYP1A2 and CYP2D6 reduces mirtazapine clearance.
What to do
Monitor for sedation, dizziness and other adverse effects, and consider reducing the mirtazapine dose if they occur. Reassess the dose when givosiran is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Mirtazapine?
MediHelp rates the interaction as moderate. Givosiran and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran reduces CYP1A2 and CYP2D6 activity, both of which contribute to mirtazapine metabolism. Mirtazapine concentrations may rise, leading to more sedation and other adverse effects.
How serious is the interaction between Givosiran and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other adverse effects, and consider reducing the mirtazapine dose if they occur. Reassess the dose when givosiran is started or stopped.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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