Drug interactions
Givosiran + Risperidone
Severity: Moderate
Givosiran and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, which may raise risperidone concentrations. Higher exposure increases the risk of extrapyramidal symptoms, sedation and hypotension, although the active moiety is affected less than parent drug.
What this interaction means in plain words
Givosiran and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Givosiran moderately inhibits CYP2D6, reducing risperidone metabolism.
What to do
Monitor for extrapyramidal symptoms and sedation. Reduce the risperidone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Risperidone?
MediHelp rates the interaction as moderate. Givosiran and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, which may raise risperidone concentrations. Higher exposure increases the risk of extrapyramidal symptoms, sedation and hypotension, although the active moiety is affected less than parent drug.
How serious is the interaction between Givosiran and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation. Reduce the risperidone dose if adverse effects occur.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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