Drug interactions
Givosiran + Ropivacaine
Severity: Moderate
Givosiran and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces CYP1A2 activity, and ropivacaine is mainly cleared by CYP1A2. Ropivacaine levels could rise, increasing the risk of systemic toxicity with prolonged or repeated dosing.
What this interaction means in plain words
Givosiran and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Ropivacaine belongs to Central Nervous System.
Why it happens
Givosiran decreases CYP1A2 activity, reducing ropivacaine metabolism.
What to do
Use the lowest effective ropivacaine dose and avoid prolonged infusions. Monitor for neurologic and cardiac signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Ropivacaine?
MediHelp rates the interaction as moderate. Givosiran and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran reduces CYP1A2 activity, and ropivacaine is mainly cleared by CYP1A2. Ropivacaine levels could rise, increasing the risk of systemic toxicity with prolonged or repeated dosing.
How serious is the interaction between Givosiran and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ropivacaine dose and avoid prolonged infusions. Monitor for neurologic and cardiac signs of toxicity.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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