Drug interactions
Givosiran + Tramadol
Severity: Moderate
Givosiran and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can moderately inhibit CYP2D6, which activates tramadol to O-desmethyltramadol. Parent tramadol may rise and analgesia may fall, with greater serotonergic and seizure risk.
What this interaction means in plain words
Givosiran and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Tramadol belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2D6 metabolism of tramadol.
What to do
Monitor analgesic response and for serotonergic or seizure effects; consider dose adjustment or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Tramadol?
MediHelp rates the interaction as moderate. Givosiran and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can moderately inhibit CYP2D6, which activates tramadol to O-desmethyltramadol. Parent tramadol may rise and analgesia may fall, with greater serotonergic and seizure risk.
How serious is the interaction between Givosiran and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and for serotonergic or seizure effects; consider dose adjustment or an alternative analgesic.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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