Drug interactions
Givosiran + Trimipramine
Severity: Moderate
Givosiran and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity and increase exposure to sensitive CYP2D6 substrates. Trimipramine levels may rise and bring more anticholinergic, sedative and cardiac effects.
What this interaction means in plain words
Givosiran and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Trimipramine belongs to Central Nervous System.
Why it happens
Givosiran-related CYP2D6 inhibition reduces trimipramine metabolism.
What to do
Consider reducing the trimipramine dose per labeling and monitor for tricyclic toxicity. Check ECG if symptoms or risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Trimipramine?
MediHelp rates the interaction as moderate. Givosiran and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity and increase exposure to sensitive CYP2D6 substrates. Trimipramine levels may rise and bring more anticholinergic, sedative and cardiac effects.
How serious is the interaction between Givosiran and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the trimipramine dose per labeling and monitor for tricyclic toxicity. Check ECG if symptoms or risk factors exist.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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