Drug interactions
Givosiran + Vortioxetine
Severity: Moderate
Givosiran and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, as shown by increased exposure to sensitive CYP2D6 substrates in studies. Since CYP2D6 is the principal route of vortioxetine clearance, vortioxetine levels may rise, increasing adverse effects such as nausea.
What this interaction means in plain words
Givosiran and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Vortioxetine belongs to Central Nervous System.
Why it happens
Givosiran reduces hepatic CYP2D6 activity, decreasing vortioxetine metabolism and raising its plasma concentration.
What to do
Monitor for increased vortioxetine adverse effects and consider a lower vortioxetine dose if tolerability is poor. Reassess the dose after givosiran is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Vortioxetine?
MediHelp rates the interaction as moderate. Givosiran and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, as shown by increased exposure to sensitive CYP2D6 substrates in studies. Since CYP2D6 is the principal route of vortioxetine clearance, vortioxetine levels may rise, increasing adverse effects such as nausea.
How serious is the interaction between Givosiran and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased vortioxetine adverse effects and consider a lower vortioxetine dose if tolerability is poor. Reassess the dose after givosiran is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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