Drug interactions
Glofitamab + Riluzole
Severity: Moderate
Glofitamab and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can transiently suppress CYP enzyme activity. Riluzole, a CYP1A2 substrate, may accumulate during this period, which could increase adverse effects such as hepatic enzyme elevation.
What this interaction means in plain words
Glofitamab and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Riluzole belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP450 enzymes by glofitamab reduces riluzole clearance.
What to do
Monitor for riluzole toxicity and liver function around glofitamab initiation and any cytokine release syndrome episodes. Adjust or hold riluzole if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Riluzole?
MediHelp rates the interaction as moderate. Glofitamab and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release that can transiently suppress CYP enzyme activity. Riluzole, a CYP1A2 substrate, may accumulate during this period, which could increase adverse effects such as hepatic enzyme elevation.
How serious is the interaction between Glofitamab and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for riluzole toxicity and liver function around glofitamab initiation and any cytokine release syndrome episodes. Adjust or hold riluzole if adverse effects develop.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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