Drug interactions
Human papillomavirus vaccine + Leflunomide
Severity: Moderate
Human papillomavirus vaccine and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide inhibits lymphocyte proliferation and may weaken responses to vaccines. The non-live HPV vaccine remains safe, but its effectiveness may be reduced.
What this interaction means in plain words
Human papillomavirus vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Leflunomide belongs to Musculoskeletal.
Why it happens
Inhibition of dihydroorotate dehydrogenase limits activated lymphocyte proliferation and antibody generation.
What to do
Vaccinate before starting leflunomide if possible, otherwise give the vaccine on schedule rather than deferring it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine with Leflunomide?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide inhibits lymphocyte proliferation and may weaken responses to vaccines. The non-live HPV vaccine remains safe, but its effectiveness may be reduced.
How serious is the interaction between Human papillomavirus vaccine and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting leflunomide if possible, otherwise give the vaccine on schedule rather than deferring it.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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