Drug interactions
Hydrochlorothiazide + Porfimer
Severity: Moderate
Hydrochlorothiazide and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides are photosensitizing agents, and porfimer causes marked photosensitivity after photodynamic therapy. Concurrent use may increase the risk or severity of skin phototoxic reactions.
What this interaction means in plain words
Hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects.
What to do
Counsel strict avoidance of direct sunlight and bright indoor light as directed after porfimer, and monitor for skin reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Porfimer
Frequently asked questions
Can I take Hydrochlorothiazide with Porfimer?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides are photosensitizing agents, and porfimer causes marked photosensitivity after photodynamic therapy. Concurrent use may increase the risk or severity of skin phototoxic reactions.
How serious is the interaction between Hydrochlorothiazide and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of direct sunlight and bright indoor light as directed after porfimer, and monitor for skin reactions.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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