Drug interactions
Hydrochlorothiazide-irbesartan + Porfimer
Severity: Moderate
Hydrochlorothiazide-irbesartan and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing and may add to the photosensitivity caused by porfimer during photodynamic therapy. This could increase the risk of skin reactions such as burns on sun exposure.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects of two agents.
What to do
Reinforce strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and consider temporary alternatives to hydrochlorothiazide if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Porfimer
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Porfimer?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is photosensitizing and may add to the photosensitivity caused by porfimer during photodynamic therapy. This could increase the risk of skin reactions such as burns on sun exposure.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reinforce strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and consider temporary alternatives to hydrochlorothiazide if needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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