Drug interactions
Ivermectin + Tucatinib
Severity: Minor
Ivermectin and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and CYP3A4 and may increase ivermectin exposure. Given ivermectin's wide safety margin, serious toxicity is unlikely but CNS effects are theoretically possible.
What this interaction means in plain words
Ivermectin and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein efflux and CYP3A4 metabolism of ivermectin.
What to do
No routine dose change is needed. Monitor for dizziness or other CNS adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ivermectin with Tucatinib?
MediHelp rates the interaction as minor. Ivermectin and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-glycoprotein and CYP3A4 and may increase ivermectin exposure. Given ivermectin's wide safety margin, serious toxicity is unlikely but CNS effects are theoretically possible.
How serious is the interaction between Ivermectin and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness or other CNS adverse effects.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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