Drug interactions
Lisdexamfetamine + Prochlorperazine
Severity: Moderate
Lisdexamfetamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotic phenothiazines may blunt the stimulant and anorectic effects of amphetamines through dopamine receptor blockade. Both agents can also affect cardiac conduction or heart rate, so arrhythmia risk may be higher in susceptible patients.
What this interaction means in plain words
Lisdexamfetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as dopamine blockade opposes amphetamine-induced dopamine release, with possible additive cardiovascular effects.
What to do
Monitor for reduced stimulant efficacy and for palpitations or ECG changes in patients with cardiac risk factors. Consider an alternative antiemetic if the stimulant response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotic phenothiazines may blunt the stimulant and anorectic effects of amphetamines through dopamine receptor blockade. Both agents can also affect cardiac conduction or heart rate, so arrhythmia risk may be higher in susceptible patients.
How serious is the interaction between Lisdexamfetamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced stimulant efficacy and for palpitations or ECG changes in patients with cardiac risk factors. Consider an alternative antiemetic if the stimulant response is lost.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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