Drug interactions
Lomustine + Secukinumab
Severity: Moderate
Lomustine and Secukinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes myelosuppression and immunosuppression, and secukinumab inhibits IL-17A, which weakens defense against some infections. Using them together may increase the likelihood of serious infections.
What this interaction means in plain words
Lomustine and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomustine belongs to Oncology; Secukinumab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from cytotoxic marrow suppression and IL-17A antagonism.
What to do
Check for active infection before starting and monitor blood counts and infection signs during treatment. Withhold secukinumab if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Lomustine with Secukinumab?
MediHelp rates the interaction as moderate. Lomustine and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes myelosuppression and immunosuppression, and secukinumab inhibits IL-17A, which weakens defense against some infections. Using them together may increase the likelihood of serious infections.
How serious is the interaction between Lomustine and Secukinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check for active infection before starting and monitor blood counts and infection signs during treatment. Withhold secukinumab if a serious infection develops.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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