Drug interactions
Maraviroc + Posaconazole
Severity: Moderate
Maraviroc and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises maraviroc concentrations, increasing the risk of dose-related effects such as postural hypotension and hepatotoxicity. Dose reduction is required when maraviroc is given with strong CYP3A4 inhibitors.
What this interaction means in plain words
Maraviroc and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of maraviroc.
What to do
Reduce maraviroc to 150 mg twice daily unless the regimen includes a CYP3A4 inducer. Monitor for hypotension and liver toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Posaconazole?
MediHelp rates the interaction as moderate. Maraviroc and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole raises maraviroc concentrations, increasing the risk of dose-related effects such as postural hypotension and hepatotoxicity. Dose reduction is required when maraviroc is given with strong CYP3A4 inhibitors.
How serious is the interaction between Maraviroc and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce maraviroc to 150 mg twice daily unless the regimen includes a CYP3A4 inducer. Monitor for hypotension and liver toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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