Drug interactions
Medroxyprogesterone + Posaconazole
Severity: Minor
Medroxyprogesterone and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise medroxyprogesterone exposure, increasing progestogenic adverse effects such as fluid retention, mood change and thromboembolic risk with higher doses. Contraceptive efficacy is not expected to decrease.
What this interaction means in plain words
Medroxyprogesterone and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of medroxyprogesterone.
What to do
No routine dose change is needed for low-dose use. Monitor for progestogenic adverse effects, particularly with high-dose oncology regimens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Posaconazole?
MediHelp rates the interaction as minor. Medroxyprogesterone and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may raise medroxyprogesterone exposure, increasing progestogenic adverse effects such as fluid retention, mood change and thromboembolic risk with higher doses. Contraceptive efficacy is not expected to decrease.
How serious is the interaction between Medroxyprogesterone and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for low-dose use. Monitor for progestogenic adverse effects, particularly with high-dose oncology regimens.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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