Drug interactions
Methamphetamine + Rolapitant
Severity: Moderate
Methamphetamine and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly metabolized by CYP2D6, and rolapitant inhibits this enzyme for a prolonged period. Exposure may rise, intensifying sympathomimetic effects such as tachycardia, hypertension and agitation.
What this interaction means in plain words
Methamphetamine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing methamphetamine metabolism.
What to do
Monitor heart rate, blood pressure and neuropsychiatric effects. Reduce the methamphetamine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Rolapitant?
MediHelp rates the interaction as moderate. Methamphetamine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is partly metabolized by CYP2D6, and rolapitant inhibits this enzyme for a prolonged period. Exposure may rise, intensifying sympathomimetic effects such as tachycardia, hypertension and agitation.
How serious is the interaction between Methamphetamine and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and neuropsychiatric effects. Reduce the methamphetamine dose if adverse effects occur.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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