Drug interactions
Methamphetamine + Solriamfetol
Severity: Moderate
Methamphetamine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Combined with methamphetamine, the cardiovascular and stimulant effects are additive, with greater risk of hypertension, tachycardia and agitation.
What this interaction means in plain words
Methamphetamine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive dopaminergic and noradrenergic stimulation through reuptake inhibition plus amphetamine-induced release.
What to do
Monitor blood pressure and heart rate regularly, and avoid the combination in uncontrolled hypertension or significant cardiovascular disease. Reduce doses if cardiovascular effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Methamphetamine with Solriamfetol?
MediHelp rates the interaction as moderate. Methamphetamine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Combined with methamphetamine, the cardiovascular and stimulant effects are additive, with greater risk of hypertension, tachycardia and agitation.
How serious is the interaction between Methamphetamine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly, and avoid the combination in uncontrolled hypertension or significant cardiovascular disease. Reduce doses if cardiovascular effects emerge.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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