Drug interactions
Metoclopramide + Perampanel
Severity: Moderate
Metoclopramide and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel commonly causes dizziness, somnolence and psychiatric effects such as irritability. Metoclopramide adds sedation and may cause extrapyramidal effects, so combined use can increase CNS adverse effects.
What this interaction means in plain words
Metoclopramide and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Counsel about sedation and avoid driving. Monitor for mood changes and movement symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Metoclopramide with Perampanel?
MediHelp rates the interaction as moderate. Metoclopramide and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel commonly causes dizziness, somnolence and psychiatric effects such as irritability. Metoclopramide adds sedation and may cause extrapyramidal effects, so combined use can increase CNS adverse effects.
How serious is the interaction between Metoclopramide and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and avoid driving. Monitor for mood changes and movement symptoms.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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