Drug interactions
Metoclopramide + Posaconazole
Severity: Moderate
Metoclopramide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can lower the exposure to posaconazole oral suspension by speeding gastric transit. Reduced antifungal levels may compromise prophylaxis or treatment of invasive fungal infection.
What this interaction means in plain words
Metoclopramide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Accelerated gastric emptying and transit reduces absorption of oral posaconazole, which depends on prolonged contact and food.
What to do
Monitor posaconazole trough concentrations and clinical response, particularly with the oral suspension. Consider the delayed-release tablet or an alternative antiemetic if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Metoclopramide with Posaconazole?
MediHelp rates the interaction as moderate. Metoclopramide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can lower the exposure to posaconazole oral suspension by speeding gastric transit. Reduced antifungal levels may compromise prophylaxis or treatment of invasive fungal infection.
How serious is the interaction between Metoclopramide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor posaconazole trough concentrations and clinical response, particularly with the oral suspension. Consider the delayed-release tablet or an alternative antiemetic if levels are low.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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