Drug interactions
Metoclopramide + Vilazodone
Severity: Moderate
Metoclopramide and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is serotonergic, so use with metoclopramide may increase serotonin syndrome risk and extrapyramidal reactions. The legacy CYP3A4 rationale is unsound since metoclopramide is not a CYP3A4 inhibitor.
What this interaction means in plain words
Metoclopramide and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects (SSRI plus 5-HT1A partial agonism) with dopamine D2 blockade.
What to do
Use the lowest metoclopramide dose for the shortest time and monitor for serotonin syndrome and dystonia. Stop metoclopramide if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Metoclopramide with Vilazodone?
MediHelp rates the interaction as moderate. Metoclopramide and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilazodone is serotonergic, so use with metoclopramide may increase serotonin syndrome risk and extrapyramidal reactions. The legacy CYP3A4 rationale is unsound since metoclopramide is not a CYP3A4 inhibitor.
How serious is the interaction between Metoclopramide and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest metoclopramide dose for the shortest time and monitor for serotonin syndrome and dystonia. Stop metoclopramide if symptoms occur.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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