Drug interactions
Metyrosine + Prochlorperazine
Severity: Moderate
Metyrosine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines including dopamine, and prochlorperazine blocks dopamine receptors, so together they raise the risk of extrapyramidal symptoms such as parkinsonism, dystonia and akathisia. The label advises caution with phenothiazines.
What this interaction means in plain words
Metyrosine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrosine belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive central dopaminergic impairment through tyrosine hydroxylase inhibition and D2 receptor blockade.
What to do
Avoid the combination if possible and use another antiemetic or antipsychotic that carries less D2 blockade. If used, monitor for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
Frequently asked questions
Can I take Metyrosine with Prochlorperazine?
MediHelp rates the interaction as moderate. Metyrosine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine depletes catecholamines including dopamine, and prochlorperazine blocks dopamine receptors, so together they raise the risk of extrapyramidal symptoms such as parkinsonism, dystonia and akathisia. The label advises caution with phenothiazines.
How serious is the interaction between Metyrosine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use another antiemetic or antipsychotic that carries less D2 blockade. If used, monitor for extrapyramidal symptoms and sedation.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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