Drug interactions
Midodrine + Solriamfetol
Severity: Moderate
Midodrine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, raises blood pressure and heart rate, and midodrine adds vasoconstriction. Combined use may lead to clinically significant hypertension.
What this interaction means in plain words
Midodrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive pressor effects from catecholamine reuptake inhibition and alpha-1 agonism.
What to do
Monitor blood pressure and heart rate and adjust midodrine or solriamfetol dose if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Midodrine with Solriamfetol?
MediHelp rates the interaction as moderate. Midodrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, raises blood pressure and heart rate, and midodrine adds vasoconstriction. Combined use may lead to clinically significant hypertension.
How serious is the interaction between Midodrine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust midodrine or solriamfetol dose if hypertension occurs.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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