Drug interactions
Mirtazapine + Rolapitant
Severity: Minor
Mirtazapine and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is metabolized by CYP2D6, CYP1A2 and CYP3A4, so CYP2D6 inhibition has only a partial effect. Mirtazapine levels may rise slightly, with more sedation or dizziness.
What this interaction means in plain words
Mirtazapine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirtazapine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, modestly reducing mirtazapine metabolism.
What to do
No routine adjustment is needed. Monitor for excess sedation and reduce the dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Rolapitant?
MediHelp rates the interaction as minor. Mirtazapine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine is metabolized by CYP2D6, CYP1A2 and CYP3A4, so CYP2D6 inhibition has only a partial effect. Mirtazapine levels may rise slightly, with more sedation or dizziness.
How serious is the interaction between Mirtazapine and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for excess sedation and reduce the dose if it occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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