Drug interactions
Mitomycin + Stiripentol
Severity: Minor
Mitomycin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and may increase systemic exposure to mitomycin. This could heighten mitomycin toxicity, especially bone marrow suppression.
What this interaction means in plain words
Mitomycin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mitomycin belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
P-glycoprotein inhibition by stiripentol may reduce mitomycin efflux.
What to do
Monitor blood counts and for mitomycin adverse effects. Reduce the mitomycin dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mitomycin and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Mitomycin with Stiripentol?
MediHelp rates the interaction as minor. Mitomycin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein and may increase systemic exposure to mitomycin. This could heighten mitomycin toxicity, especially bone marrow suppression.
How serious is the interaction between Mitomycin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for mitomycin adverse effects. Reduce the mitomycin dose if toxicity occurs.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
