Drug interactions
Modafinil + Solriamfetol
Severity: Moderate
Modafinil and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote wakefulness and can raise blood pressure and heart rate. Used together they may produce additive cardiovascular and CNS stimulation including anxiety and insomnia.
What this interaction means in plain words
Modafinil and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive dopaminergic and noradrenergic stimulation with pressor effects.
What to do
Avoid routine combination; if used, monitor blood pressure and heart rate and reduce a dose if stimulation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Modafinil with Solriamfetol?
MediHelp rates the interaction as moderate. Modafinil and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote wakefulness and can raise blood pressure and heart rate. Used together they may produce additive cardiovascular and CNS stimulation including anxiety and insomnia.
How serious is the interaction between Modafinil and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, monitor blood pressure and heart rate and reduce a dose if stimulation occurs.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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