Drug interactions
Nintedanib + Posaconazole
Severity: Moderate
Nintedanib and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase nintedanib exposure, raising the risk of diarrhoea, nausea, vomiting and liver enzyme elevation. Nintedanib is a P-glycoprotein substrate and a minor CYP3A4 substrate.
What this interaction means in plain words
Nintedanib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits P-glycoprotein (and CYP3A4), reducing nintedanib efflux and clearance.
What to do
Monitor for gastrointestinal adverse effects and liver enzymes. Manage toxicity by interrupting or reducing the nintedanib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Posaconazole?
MediHelp rates the interaction as moderate. Nintedanib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase nintedanib exposure, raising the risk of diarrhoea, nausea, vomiting and liver enzyme elevation. Nintedanib is a P-glycoprotein substrate and a minor CYP3A4 substrate.
How serious is the interaction between Nintedanib and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and liver enzymes. Manage toxicity by interrupting or reducing the nintedanib dose.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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