Drug interactions
Ozanimod + Rolapitant
Severity: Moderate
Ozanimod and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits BCRP and may raise exposure to the active metabolites of ozanimod. This could increase ozanimod adverse effects such as bradycardia, hepatic enzyme elevation and infection risk.
What this interaction means in plain words
Ozanimod and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits intestinal BCRP, which may increase absorption and exposure of ozanimod active metabolites.
What to do
Monitor heart rate, liver enzymes and signs of adverse effects when rolapitant is used with ozanimod. Rolapitant is given as a single dose per chemotherapy cycle, so the exposure is limited.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Rolapitant?
MediHelp rates the interaction as moderate. Ozanimod and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits BCRP and may raise exposure to the active metabolites of ozanimod. This could increase ozanimod adverse effects such as bradycardia, hepatic enzyme elevation and infection risk.
How serious is the interaction between Ozanimod and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, liver enzymes and signs of adverse effects when rolapitant is used with ozanimod. Rolapitant is given as a single dose per chemotherapy cycle, so the exposure is limited.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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