Drug interactions
Perampanel + Posaconazole
Severity: Moderate
Perampanel and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel is metabolized by CYP3A4, so posaconazole may raise its levels and increase dizziness, somnolence, ataxia and psychiatric adverse effects. The expected increase with strong inhibitors is modest.
What this interaction means in plain words
Perampanel and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perampanel belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by posaconazole reduces perampanel clearance.
What to do
Monitor for CNS adverse effects and mood or behavior changes, and lower the perampanel dose if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Perampanel with Posaconazole?
MediHelp rates the interaction as moderate. Perampanel and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel is metabolized by CYP3A4, so posaconazole may raise its levels and increase dizziness, somnolence, ataxia and psychiatric adverse effects. The expected increase with strong inhibitors is modest.
How serious is the interaction between Perampanel and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and mood or behavior changes, and lower the perampanel dose if they emerge.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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