Drug interactions
Posaconazole + Talazoparib
Severity: Moderate
Posaconazole and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits P-glycoprotein and may increase talazoparib exposure. Higher concentrations could worsen myelosuppression such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Posaconazole and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Talazoparib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of talazoparib increases its absorption and reduces its elimination.
What to do
Prefer an antifungal without P-gp inhibition if possible; otherwise consider reducing the talazoparib dose per labeling for P-gp inhibitors and monitor blood counts regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Posaconazole with Talazoparib?
MediHelp rates the interaction as moderate. Posaconazole and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits P-glycoprotein and may increase talazoparib exposure. Higher concentrations could worsen myelosuppression such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Posaconazole and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal without P-gp inhibition if possible; otherwise consider reducing the talazoparib dose per labeling for P-gp inhibitors and monitor blood counts regularly.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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