Drug interactions
Posaconazole + Tasimelteon
Severity: Minor
Posaconazole and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase tasimelteon exposure because tasimelteon is metabolized partly by CYP3A4. This may increase somnolence, headache or other adverse effects.
What this interaction means in plain words
Posaconazole and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Tasimelteon belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by posaconazole reduces tasimelteon metabolism; CYP1A2 is the main pathway, so the effect is limited.
What to do
No routine dose change is required; monitor for excess sedation or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Posaconazole with Tasimelteon?
MediHelp rates the interaction as minor. Posaconazole and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase tasimelteon exposure because tasimelteon is metabolized partly by CYP3A4. This may increase somnolence, headache or other adverse effects.
How serious is the interaction between Posaconazole and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for excess sedation or dizziness.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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