Drug interactions
Posaconazole + Tepotinib
Severity: Moderate
Posaconazole and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib is a P-glycoprotein inhibitor and posaconazole is a P-gp substrate, so posaconazole exposure may rise modestly. The clinical significance is uncertain, but higher posaconazole levels could increase adverse effects such as QT prolongation and hepatotoxicity.
What this interaction means in plain words
Posaconazole and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-glycoprotein efflux, potentially increasing posaconazole absorption and reducing its clearance.
What to do
Monitor for posaconazole adverse effects and consider checking posaconazole trough concentrations if therapeutic drug monitoring is available. Use an ECG if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Posaconazole with Tepotinib?
MediHelp rates the interaction as moderate. Posaconazole and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib is a P-glycoprotein inhibitor and posaconazole is a P-gp substrate, so posaconazole exposure may rise modestly. The clinical significance is uncertain, but higher posaconazole levels could increase adverse effects such as QT prolongation and hepatotoxicity.
How serious is the interaction between Posaconazole and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for posaconazole adverse effects and consider checking posaconazole trough concentrations if therapeutic drug monitoring is available. Use an ECG if other QT-prolonging drugs are present.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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