Drug interactions
Posaconazole + Tucatinib
Severity: Minor
Posaconazole and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and could increase posaconazole absorption and exposure. Tucatinib also inhibits CYP3A4, but posaconazole is mainly cleared by UGT glucuronidation, so the clinical impact is likely modest.
What this interaction means in plain words
Posaconazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Tucatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by tucatinib may increase posaconazole exposure.
What to do
No empirical dose adjustment is needed; monitor for posaconazole adverse effects such as gastrointestinal upset and liver enzyme elevations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Posaconazole with Tucatinib?
MediHelp rates the interaction as minor. Posaconazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-glycoprotein and could increase posaconazole absorption and exposure. Tucatinib also inhibits CYP3A4, but posaconazole is mainly cleared by UGT glucuronidation, so the clinical impact is likely modest.
How serious is the interaction between Posaconazole and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for posaconazole adverse effects such as gastrointestinal upset and liver enzyme elevations.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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