Drug interactions
Posaconazole + Vilazodone
Severity: Moderate
Posaconazole and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases vilazodone exposure, which may increase serotonergic and gastrointestinal adverse effects.
What this interaction means in plain words
Posaconazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Vilazodone belongs to Central Nervous System.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of vilazodone.
What to do
Cap vilazodone at 20 mg daily during strong CYP3A4 inhibition and watch for serotonin toxicity; return to the prior dose after posaconazole stops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Posaconazole with Vilazodone?
MediHelp rates the interaction as moderate. Posaconazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases vilazodone exposure, which may increase serotonergic and gastrointestinal adverse effects.
How serious is the interaction between Posaconazole and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Cap vilazodone at 20 mg daily during strong CYP3A4 inhibition and watch for serotonin toxicity; return to the prior dose after posaconazole stops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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