Drug interactions
Ranolazine + Silodosin
Severity: Moderate
Ranolazine and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and silodosin is a P-gp substrate, so silodosin exposure may rise. This could increase alpha-blocker adverse effects such as orthostatic hypotension, dizziness and ejaculatory disorders.
What this interaction means in plain words
Ranolazine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Inhibition of P-glycoprotein efflux by ranolazine, possibly increasing silodosin absorption and exposure.
What to do
Monitor for orthostatic hypotension and dizziness when ranolazine is started or the dose is raised. Reduce the silodosin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ranolazine and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Silodosin?
MediHelp rates the interaction as moderate. Ranolazine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein and silodosin is a P-gp substrate, so silodosin exposure may rise. This could increase alpha-blocker adverse effects such as orthostatic hypotension, dizziness and ejaculatory disorders.
How serious is the interaction between Ranolazine and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness when ranolazine is started or the dose is raised. Reduce the silodosin dose if adverse effects appear.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
