Drug interactions
Repotrectinib + Rolapitant
Severity: Moderate
Repotrectinib and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits P-glycoprotein and may increase repotrectinib exposure. This could heighten dose-related toxicities such as neurological effects, dizziness and hepatotoxicity.
What this interaction means in plain words
Repotrectinib and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repotrectinib belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits intestinal P-gp efflux, increasing absorption of repotrectinib.
What to do
Monitor for neurological adverse effects and liver enzymes if both are given. Rolapitant is a single dose per cycle, but its inhibitory effect persists for days given its long half-life.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repotrectinib with Rolapitant?
MediHelp rates the interaction as moderate. Repotrectinib and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits P-glycoprotein and may increase repotrectinib exposure. This could heighten dose-related toxicities such as neurological effects, dizziness and hepatotoxicity.
How serious is the interaction between Repotrectinib and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurological adverse effects and liver enzymes if both are given. Rolapitant is a single dose per cycle, but its inhibitory effect persists for days given its long half-life.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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