Drug interactions
Riluzole + Teriflunomide
Severity: Moderate
Riluzole and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riluzole is cleared mainly by CYP1A2, which teriflunomide weakly induces. Riluzole levels may fall slightly, though the effect is likely small. Both drugs can cause liver enzyme elevation.
What this interaction means in plain words
Riluzole and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riluzole belongs to Miscellaneous; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak CYP1A2 induction by teriflunomide may increase riluzole clearance, with additive hepatotoxic potential.
What to do
Monitor liver enzymes and clinical response to riluzole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Frequently asked questions
Can I take Riluzole with Teriflunomide?
MediHelp rates the interaction as moderate. Riluzole and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riluzole is cleared mainly by CYP1A2, which teriflunomide weakly induces. Riluzole levels may fall slightly, though the effect is likely small. Both drugs can cause liver enzyme elevation.
How serious is the interaction between Riluzole and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and clinical response to riluzole.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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