Drug interactions
Risperidone + Rolapitant
Severity: Minor
Risperidone and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is converted to active 9-hydroxyrisperidone by CYP2D6, and rolapitant inhibits this enzyme for weeks. The parent drug level rises while the active metabolite falls, so the total active moiety changes little, but tolerability may be affected.
What this interaction means in plain words
Risperidone and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Risperidone belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing conversion of risperidone to 9-hydroxyrisperidone.
What to do
No empirical dose change is needed. Monitor for extrapyramidal symptoms, sedation and hypotension, and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Rolapitant?
MediHelp rates the interaction as minor. Risperidone and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone is converted to active 9-hydroxyrisperidone by CYP2D6, and rolapitant inhibits this enzyme for weeks. The parent drug level rises while the active metabolite falls, so the total active moiety changes little, but tolerability may be affected.
How serious is the interaction between Risperidone and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for extrapyramidal symptoms, sedation and hypotension, and adjust the dose as needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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