Drug interactions
Rolapitant + Rucaparib
Severity: Minor
Rolapitant and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor, and rolapitant is metabolized by CYP3A4. Any increase in rolapitant exposure is expected to be modest.
What this interaction means in plain words
Rolapitant and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rolapitant belongs to Gastrointestinal Tract; Rucaparib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by rucaparib may reduce rolapitant metabolism.
What to do
No dose adjustment is usually needed. Monitor for rolapitant adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rolapitant with Rucaparib?
MediHelp rates the interaction as minor. Rolapitant and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor, and rolapitant is metabolized by CYP3A4. Any increase in rolapitant exposure is expected to be modest.
How serious is the interaction between Rolapitant and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for rolapitant adverse effects.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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