Drug interactions
Rolapitant + Temsirolimus
Severity: Moderate
Rolapitant and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits P-glycoprotein and may increase concentrations of P-gp substrates such as temsirolimus and its active metabolite sirolimus. This could heighten adverse effects such as myelosuppression, mucositis, and metabolic disturbances.
What this interaction means in plain words
Rolapitant and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Temsirolimus belongs to Oncology.
Why it happens
Rolapitant inhibits P-gp efflux, which may reduce clearance of temsirolimus.
What to do
Monitor blood counts and for temsirolimus toxicity when rolapitant is used. Reduce temsirolimus dosing if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Rolapitant with Temsirolimus?
MediHelp rates the interaction as moderate. Rolapitant and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits P-glycoprotein and may increase concentrations of P-gp substrates such as temsirolimus and its active metabolite sirolimus. This could heighten adverse effects such as myelosuppression, mucositis, and metabolic disturbances.
How serious is the interaction between Rolapitant and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for temsirolimus toxicity when rolapitant is used. Reduce temsirolimus dosing if adverse effects develop.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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