Drug interactions
Rolapitant + Valbenazine
Severity: Moderate
Rolapitant and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant is a prolonged CYP2D6 inhibitor and may raise exposure to the active metabolite of valbenazine, which is partly cleared by CYP2D6. This may increase somnolence and QT prolongation risk.
What this interaction means in plain words
Rolapitant and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Valbenazine belongs to Central Nervous System.
Why it happens
Rolapitant inhibits CYP2D6, reducing clearance of the active metabolite of valbenazine.
What to do
Monitor for sedation and QT effects, and consider a valbenazine dose reduction if adverse effects occur. The inhibitory effect of rolapitant can last at least 28 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Rolapitant with Valbenazine?
MediHelp rates the interaction as moderate. Rolapitant and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant is a prolonged CYP2D6 inhibitor and may raise exposure to the active metabolite of valbenazine, which is partly cleared by CYP2D6. This may increase somnolence and QT prolongation risk.
How serious is the interaction between Rolapitant and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and QT effects, and consider a valbenazine dose reduction if adverse effects occur. The inhibitory effect of rolapitant can last at least 28 days.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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