Drug interactions
Rolapitant + Vortioxetine
Severity: Moderate
Rolapitant and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine is mainly cleared by CYP2D6, and rolapitant inhibits this enzyme for a prolonged period. Exposure may increase, leading to more nausea and other adverse effects.
What this interaction means in plain words
Rolapitant and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Vortioxetine belongs to Central Nervous System.
Why it happens
Rolapitant inhibits CYP2D6, reducing vortioxetine clearance.
What to do
Monitor tolerability, especially nausea, and consider reducing the vortioxetine dose. Remember the inhibition persists for weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Rolapitant with Vortioxetine?
MediHelp rates the interaction as moderate. Rolapitant and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine is mainly cleared by CYP2D6, and rolapitant inhibits this enzyme for a prolonged period. Exposure may increase, leading to more nausea and other adverse effects.
How serious is the interaction between Rolapitant and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tolerability, especially nausea, and consider reducing the vortioxetine dose. Remember the inhibition persists for weeks.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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